¤¬¤óºÙ˦¤Ç¤ÏDNA¤Ë̲¤ë¸ÅÂå¤Î¥¦¥¤¥ë¥¹¤¬¡Ö³ÐÀáפ·¤Æ¤¤¤ë¤È¤Î¸¦µæ·ë²Ì¡¢¤¬¤ó¼£ÎŤ˱þÍѤǤ¤ë²ÄǽÀ¤â
![](https://image.news.livedoor.com/newsimage/stf/c/5/c5d97_88_bfcfec8fca62249e18df5a6dcdbd0061.jpg)
¿Í¤Î°äÅÁ»Ò¤ÎÌó8¡ó¤Ï¡¢¿ÍÎà¤ÎÁÄÀè¤Ë´¶À÷¤·¤¿¥¦¥¤¥ë¥¹¤Î̾»Ä¤Ç¤¢¤ë¡ÖÆâºßÀ¥ì¥È¥í¥¦¥¤¥ë¥¹¡×¤À¤È¸À¤ï¤ì¤Æ¤ª¤ê¡¢Ç¾¤Î³èÀ¤äÌôʪÃæÆǤؤαƶÁ¤Ê¤É¤Î·Á¤Çº£¤Ê¤ª¿ÍÎà¤Ë±Æ¶Á¤òµÚ¤Ü¤·¤Æ¤¤¤Þ¤¹¡£¤½¤ó¤Ê¥¦¥¤¥ë¥¹¤Î°äÅÁ»Ò¤¬¡¢¤¬¤ó¤ÎȯÀ¸¤ä°²½¤Ë¤â´ØÍ¿¤·¤Æ¤¤¤ë²ÄǽÀ¤¬¤¢¤ë¤³¤È¤¬Æͤ»ß¤á¤é¤ì¤Þ¤·¤¿¡£
Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer | Science Advances
Ancient viruses fuel modern-day cancers | CU Boulder Today | University of Colorado Boulder
https://www.colorado.edu/today/2024/07/17/ancient-viruses-fuel-modern-day-cancers
¥³¥í¥é¥ÉÂç³Ø¥Ü¥ë¥À¡¼¹»¥Ð¥¤¥ª¥Õ¥í¥ó¥Æ¥£¥¢¸¦µæ½ê¤Î¥²¥Î¥àÀ¸Êª³Ø¼Ô¤Ç¤¢¤ë¥¨¥É¥ï¡¼¥É¡¦¥Á¥å¥ª¥ó»á¤Ë¤è¤ë¤È¡¢°äÅÁ»Ò¤ÎÃæ¤Ë»Ä¤ëÆâºßÀ¥ì¥È¥í¥¦¥¤¥ë¥¹¤Ë¤Ï¿·¤·¤¯¥¦¥¤¥ë¥¹¤òºî¤ëǽÎϤ³¤½¤Ê¤¤¤â¤Î¤Î¡¢ÉÕ¶á¤Ë¤¢¤ë°äÅÁ»Ò¤Îȯ¸½¤ò¥ª¥ó¤Ë¤¹¤ë¥¹¥¤¥Ã¥Á¤È¤·¤Æ¤Îµ¡Ç½¤ò»ý¤Ä¤È¤Î¤³¤È¡£¤½¤ÎÃæ¤Ë¤Ï¡¢ÂÛÈפÎȯã¤ä¿··¿¥³¥í¥Ê¥¦¥¤¥ë¥¹¤ËÂФ¹¤ëÌȱÖÈ¿±þ¤Ê¤É¡¢¸½À¸¿ÍÎà¤Ë¤È¤Ã¤Æ½ÅÍפʵ¡Ç½¤Ë¹×¸¥¤·¤Æ¤¤¤ë¤â¤Î¤â¤¢¤ê¤Þ¤¹¡£
¤³¤Î¤è¤¦¤ÊÆâºßÀ¥ì¥È¥í¥¦¥¤¥ë¥¹¤Î¥á¥ê¥Ã¥È¤Ë´Ø¤¹¤ë¸¦µæ¤ÏÀ¹¤ó¤Ë¹Ô¤ï¤ì¤Æ¤¤¤Þ¤¹¤¬¡¢¿ÍÂΤ˵ڤܤ¹³²¤Ë¤Ä¤¤¤Æ¤Î¸¦µæ¤Ï¤¢¤Þ¤ê¹Ô¤ï¤ì¤Æ¤¤¤Þ¤»¤ó¡£
ÆâºßÀ¥ì¥È¥í¥¦¥¤¥ë¥¹¤¬¡¢À¤³¦¤Î»à°ø¤Î6ʬ¤Î1¤òÀê¤á¤ë¤¬¤ó¤Ë¤É¤¦±Æ¶Á¤·¤Æ¤¤¤ë¤Î¤«¤òÄ´¤Ù¤ë¤¿¤á¡¢¥Á¥å¥ª¥ó»á¤é¤Î¸¦µæ¥Á¡¼¥à¤Ï¸ø³«¤µ¤ì¤Æ¤¤¤ë¥Ç¡¼¥¿¥»¥Ã¥È¤«¤é21¼ïÎà¤Î¤¬¤ó¤Î¥²¥Î¥à¥Ç¡¼¥¿¤òÃê½Ð¤·¤ÆʬÀϤ·¤Þ¤·¤¿¡£
¤½¤Î·ë²Ì¡¢¸¦µæ¥Á¡¼¥à¤ÏÌó3000ËüǯÁ°¤Ë°ìÉô¤ÎÎîĹÎà¤Ë´¶À÷¤·¤¿¥¦¥¤¥ë¥¹¤¬»Ä¤·¤¿°äÅÁ»Ò¤Ç¤¢¤ë¡ÖLTR10¡×¤¬¡¢ÇÙ¤¬¤ó¤äÂçIJ¤¬¤ó¤ò´Þ¤à¿ô¼ïÎà¤Î¤¬¤ó¤Ç¶Ã¤¯¤Û¤É¹â¤¤¥ì¥Ù¥ë¤Î³èÀ¤ò¼¨¤·¤Æ¤¤¤¿¤³¤È¤òȯ¸«¤·¤Þ¤·¤¿¡£¤µ¤é¤Ë¡¢ÂçIJ¤¬¤ó´µ¼Ô¤Î¼ðáç¤òʬÀϤ·¤¿¤È¤³¤í¡¢´µ¼Ô¤Î3ʬ¤Î1¤ÇLTR10¤¬³èÀ²½¤·¤Æ¤¤¤Þ¤·¤¿¡£
![](https://image.news.livedoor.com/newsimage/stf/0/3/03feb_88_2c02a115ce9bf39d8f4344684934efcf.jpg)
»î¤·¤Ë¡¢¸¦µæ¥Á¡¼¥à¤¬°äÅÁ»ÒÊÔ½¸µ»½Ñ¤ÎCRISPR¤ÈÇÝÍܤ·¤¿¥Ò¥È¤Î¤¬¤óºÙ˦¤ò»È¤Ã¤Æ¡¢ÌäÂê¤Î°äÅÁ»ÒÇÛÎó¤òÀÚ½ü¤·¤¿¤ê¥µ¥¤¥ì¥ó¥·¥ó¥°(°äÅÁ»Ò¤Î¥¹¥¤¥Ã¥Á¤ò¥ª¥Õ¤Ë¤¹¤ë¤³¤È)¤ò¤·¤¿¤ê¤¹¤ë¼Â¸³¤ò¹Ô¤Ã¤¿¤È¤³¤í¡¢¤¬¤ó¤ÎȯÀ¸¤äÀ®Ä¹¤ÎÂ¥¿Ê¤Ë´ØÍ¿¤¹¤ë°äÅÁ»Ò¤â¤Ê¤¯¤Ê¤ê¤Þ¤·¤¿¡£
¤µ¤é¤Ë¡¢¥Þ¥¦¥¹¤ò»È¤Ã¤¿¼Â¸³¤Ç¤Ï¡¢¤¬¤óºÙ˦¤«¤éLTR10¤ò¼è¤ê½ü¤¯¤³¤È¤Ç¤¬¤óºÙ˦¤ÎÀ¸Â¸¤Ë´ØÏ¢¤·¤¿°äÅÁ»Ò¤Ç¤¢¤ë¡ÖXRCC4¡×¤â¥ª¥Õ¤Ë¤Ê¤ê¡¢¤³¤ì¤Ë¤è¤Ã¤Æ¼ðáç¤ò½Ì¾®¤µ¤»¤ë¤¬¤ó¼£ÎŤθú²Ì¤ò¹â¤á¤ë¤³¤È¤ËÀ®¸ù¤·¤Þ¤·¤¿¡£
¤¬¤óºÙ˦¤Ç¤Ï¡¢¡ÖMAP¥¥Ê¡¼¥¼·ÐÏ©¡×¤È¤è¤Ð¤ì¤ëºÙ˦Æ⥷¥¹¥Æ¥à¤¬¾ï»þ¥ª¥ó¤Ë¤Ê¤Ã¤Æ¤ª¤ê¡¢¤½¤ÎƯ¤¤òÁ˳²¤¹¤ë¡ÖMAP¥¥Ê¡¼¥¼Á˳²Ìô¡×¤È¤¤¤¦¤¬¤ó¼£ÎÅÌô¤¬¹¤¯ÍѤ¤¤é¤ì¤Æ¤¤Þ¤·¤¿¡£¥Á¥å¥ª¥ó»á¤é¤Î¸¦µæ¤Ç¤Ï¡¢ÆâºßÀ¥ì¥È¥í¥¦¥¤¥ë¥¹¤¬¤³¤ÎMAP¥¥Ê¡¼¥¼·ÐÏ©¤Î°äÅÁ»Ò¤ò¥ª¥ó¤Ë¤·¤Æ¤¤¤ë²ÄǽÀ¤¬¼¨¤µ¤ì¤Æ¤ª¤ê¡¢¤³¤Î¤³¤È¤«¤é¡Ö¤¬¤ó¼£ÎÅÌô¤¬¸ú¤¯¤Î¤ÏÆâºßÀ¥ì¥È¥í¥¦¥¤¥ë¥¹¤¬¥ª¥ó¤Ë¤·¤¿¥¹¥¤¥Ã¥Á¤ò¥ª¥Õ¤Ë¤·¤Ê¤ª¤¹¤«¤é¤Ç¤Ï¤Ê¤¤¤«¡×¤È¤¤¤¦¤³¤È¤¬¼¨º¶¤µ¤ì¤Æ¤¤¤Þ¤¹¡£
¥Á¥å¥ª¥ó»á¤Ë¤è¤ë¤È¡¢¤¬¤óºÙ˦¤Ç¤ÏËÜÍè³èÀ²½¤¹¤Ù¤¤Ç¤Ï¤Ê¤¤°äÅÁ»Ò¤¬Â¿¿ôȯ¸½¤·¤Æ¤¤¤ë¤³¤È¤¬¤ï¤«¤Ã¤Æ¤¤¤¿¤â¤Î¤Î¡¢¤Ê¤¼¤½¤Î¤è¤¦¤Ê°äÅÁ»Ò¤¬³èÀ²½¤µ¤ì¤Æ¤¤¤ë¤Î¤«¤ÏÉÔÌÀ¤À¤Ã¤¿¤È¤Î¤³¤È¡£¤·¤«¤·¡¢º£²ó¤Î¸¦µæ¤Ë¤è¤ê¡¢¤¬¤óºÙ˦¤ò°ú¤µ¯¤³¤¹¥¹¥¤¥Ã¥Á¤Î¿¤¯¤Ï¸ÅÂå¤Î¥¦¥¤¥ë¥¹¤¬´ØÍ¿¤·¤Æ¤¤¤ë¤³¤È¤¬ÌÀ¤é¤«¤Ë¤Ê¤ê¤Þ¤·¤¿¡£
![](https://image.news.livedoor.com/newsimage/stf/e/d/ed6e2_88_a624f771e4c0f96c02b99e8a614f596d.jpg)
¸ÅÂå¤Î¥¦¥¤¥ë¥¹¤È¤¬¤ó¤Î´Ø·¸¤ò¼¨¤¹¸¦µæ¤Ï¡¢¤³¤ì¤¬ºÇ½é¤Ç¤Ï¤¢¤ê¤Þ¤»¤ó¡£°ÊÁ°¤Ë¤â¡¢ÆâºßÀ¥ì¥È¥í¥¦¥¤¥ë¥¹¤¬ÆÇÀ¤Î¤¢¤ë²½¹çʪ¤òÊü½Ð¤·¤¿¤ê¡¢°äÅÁ»ÒÊÑ°Û¤ò°ú¤±Û¤·¤¿¤ê¤¹¤ë¤³¤È¤¬¼¨º¶¤µ¤ì¤Æ¤¤¤ë¤Û¤«¡¢¥¦¥¤¥ë¥¹¤¬Çò·ìɤäÁ°Î©Á£¤¬¤ó¤ÎºÙ˦·ÐÏ©¤ò³èÀ²½¤µ¤»¤ë¤³¤È¤ò¼¨¤¹¸¦µæ¤âÊó¹ð¤µ¤ì¤Æ¤¤¤Þ¤¹¡£
º£²ó¤Î¸¦µæ¤Ç¤Ï¡¢¸ÅÂå¤Î¥¦¥¤¥ë¥¹¤¬¤¬¤ó¤ËµÚ¤Ü¤¹¿·¤·¤¤±Æ¶Á¤¬¤ï¤«¤ê¤Þ¤·¤¿¤¬¡¢¤³¤ì¤Ï¡ÖÆâºßÀ¥ì¥È¥í¥¦¥¤¥ë¥¹¤¬¤¬¤ó¤ò°ú¤µ¯¤³¤·¤Æ¤¤¤ë¡×¤È¤¤¤¦¤³¤È¤ò¼¨¤·¤Æ¤¤¤ë¤ï¤±¤Ç¤Ï¤Ê¤¤¤È¥Á¥å¥ª¥ó»á¤Ï¹Í¤¨¤Æ¤¤¤Þ¤¹¡£
¤à¤·¤í¡¢¤¬¤óºÙ˦¤¬¤½¤ì¤é¤Î¥¦¥¤¥ë¥¹¤òÌܳФᤵ¤»¤Æ¤¬¤ó¤ÎÀ¸Â¸ÎϤò¹â¤á¤ë¤Î¤ËÍøÍѤ·¤¿¤ê¡¢ºÙ˦¤¬Ï·²½¤·¤Æ¥²¥Î¥à¤Î½¤Éüµ¡Ç½¤¬Íî¤Á¤¿»þ¤Ë¸ÅÂå¤Î¥¦¥¤¥ë¥¹¤¬ÌܳФá¤Æ¡¢¤Û¤«¤Î·ò¹¯ÌäÂê¤Ë¤Ä¤Ê¤¬¤ë¥×¥í¥»¥¹¤ò³èÀ²½¤µ¤»¤¿¤ê¤·¤Æ¤¤¤ë¤È¹Í¤¨¤ëÊý¤¬¼«Á³¤À¤È¤Î¤³¤È¡£
¥Á¥å¥ª¥ó»á¤Ï¡Ö¤É¤Î¤è¤¦¤Ë¤·¤Æɵ¤¤¬ºÙ˦Æâ¤Ë¸½¤ì¤ë¤Î¤«¡¢¤½¤Îµ¯¸»¤Ï¾ï¤ËÆæ¤Ç¤·¤¿¡£ÆâºßÀ¥ì¥È¥í¥¦¥¤¥ë¥¹¤¬¤¹¤Ù¤Æ¤Î¸µ¶§¤È¤¤¤¦¤ï¤±¤Ç¤Ï¤¢¤ê¤Þ¤»¤ó¤¬¡¢¤½¤ÎÂçÉôʬ¤òÀê¤á¤Æ¤¤¤ë²ÄǽÀ¤¬¤¢¤ê¤Þ¤¹¡×¤È½Ò¤Ù¤Þ¤·¤¿¡£